Anti-CTNNBL1 Antibody Picoband® 31.0550 Vervoeging

Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene. The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome.

CTNNBL1; C20orf33; PP8304; Beta-catenin-like protein 1; Nuclear-associated protein; NAP; Testis development protein NYD-SP19

CTNNBL1

56259

Q8WYA6

Human

No cross-reactivity with other proteins

E.coli-derived human CTNNBL1 recombinant protein (Position: Q122-E231) . Human CTNNBL1 shares 97.3% and 98.2% amino acid (aa) sequence identity with mouse and rat CTNNBL1, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Conticello, S. G., Ganesh, K., Xue, K., Lu, M., Rada, C., Neuberger, M. S. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Molec. Cell 31: 474-484, 2008. 2. Ganesh, K., Adam, S., Taylor, B., Simpson, P., Rada, C., Neuberger, M. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. J. Biol. Chem. 286: 17091-17102, 2011. 3. Jabbour, L., Welter, J. F., Kollar, J., Hering, T. M. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics 81: 292-303, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

65 kDa

6

Catenin beta like 1

Beta-catenin-like protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.