Anti-CTRL Antibody Picoband® 0,00647 Vervoeging

Chymotrypsin-like protease CTRL-1 is an enzyme that in humans is encoded by the CTRL gene. This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme.

PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80; PHF21A; BHC80; KIAA1696; BM-006

CTRL

1506

P40313

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human CTRL recombinant protein (Position: I34-N264) .

Highly expressed in brain. Expressed at much lower level in other tissues.

Flow Cytometry

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Immunogen affinity purified.

Liquid

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.

1. Larsen, F., Solheim, J., Kristensen, T., Kolsto, A.-B., Prydz, H. A tight cluster of five unrelated human genes on chromosome 16q22.1. Hum. Molec. Genet. 2: 1589-1595, 1993. 2. Reseland, J. E., Larsen, F., Solheim, J., Eriksen, J. A., Hanssen, L. E., Prydz, H. A novel human chymotrypsin-like digestive enzyme. J. Biol. Chem. 272: 8099-8104, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

PHD finger protein 21A

Nucleus.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.