Anti-CUX1 Antibody Picoband®

The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.

Boster Bio Anti-CUX1 Antibody Picoband® catalog # A01653-4. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Protein scribble homolog; Scribble; hScrib; Protein LAP4; SCRIB; CRIB1; KIAA0147; LAP4; SCRB1; VARTUL

CUX1

1523

P39880

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human CUX1 recombinant protein (Position: M1-E220) .

Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level) .

ELISA, Flow Cytometry, IHC, WB

Microbiology

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.

1. Cubelos, B., Sebastian-Serrano, A., Beccari, L., Calcagnotto, M. E., Cisneros, E., Kim, S., Dopazo, A., Alvarez-Dolado, M., Redondo, J. M., Bovolenta, P., Walsh, C. A., Nieto, M. Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex. Neuron 66: 523-535, 2010. 2. Doan, R. N., Bae, B.-I., Cubelos, B., Chang, C., Hossain, A. A., Al-Saad, S., Mukaddes, N. M., Oner, O., Al-Saffar, M., Balkhy, S., Gascon G. G., The Homozygosity Mapping Consortium for Autism, Nieto, M., Walsh, C. A. Mutations in human accelerated regions disrupt cognition and social behavior. Cell 167: 341-354, 2016. 3. Gillingham, A. K., Pfeifer, A. C., Munro, S. CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin. Molec. Biol. Cell. 13: 3761-3774, 2002.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A01653-4

50514 MW

200 kDa

6

Scribbled planar cell polarity protein

Cell membrane.

Carboxypeptidase M

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.