Anti-CXCR1 Antibody Picoband® 31.0550 Vervoeging

CXCR1 (Chemokine, CXC Motif, Receptor 1), also known as IL8RA or IL8R1, is a chemokine receptor. IL8RA is its human gene. Morris et al. (1992) mapped the IL8RA gene to chromosome 2q35. Hartl et al. (2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CD181; CXCR1; CMKAR1, IL8RA

CXCR1

3577

P25024

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR1.

Endothelial tissues and brain.

Flow Cytometry

Cancer, Chemokines, Cytokines, Immunology, Innate Immunity, Tumor Immunology

Immunogen affinity purified.

Liquid

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

1. Hartl, D., Latzin, P., Hordijk, P., Marcos, V., Rudolph, C., Woischnik, M., Krauss-Etschmann, S., Koller, B., Reinhardt, D., Roscher, A. A., Roos, D., Griese, M. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nature Med. 13: 1423-1430, 2007. 2. Morris, S. W., Nelson, N., Valentine, M. B., Shapiro, D. N., Look, A. T., Kozlosky, C. J., Beckmann, M. P., Cerretti, D. P. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. Genomics 14: 685-691, 1992. 3. Vasilescu, A., Terashima, Y., Enomoto, M., Heath, S., Poonpiriya, V., Gatanaga, H., Do, H., Diop, G., Hirtzig, T., Auewarakul, P., Lauhakirti, D., Sura, T., Charneau, P., Marullo, S., Therwath, A., Oka, S., Kanegasaki, S., Lathrop, M., Matsushima, K., Zagury, J.-F., Matsuda, F. A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients. Proc. Nat. Acad. Sci. 104: 3354-3359, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39791 MW

No cross reactivity with other proteins.

6

C-X-C chemokine receptor type 1

Cell membrane; Multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family.

C-X-C chemokine receptor type 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.