Anti-CXCR3 Antibody Picoband® 31.0647 Vervoeging

Chemokine receptor CXCR3 is a Galphai protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. It is mapped to Xq13.1. CXCR3 is expressed on malignant B cells from chronic lymphoproliferative disorders, particularly in patients with CLL, and represents a fully functional receptor involved in chemotaxis of malignant B lymphocytes. It is found that in the absence of known etiologic agents, CXCR3 represents a novel target for therapeutic interference early in type 1 diabetes. CXCR3 signaling is associated with MG pathogenesis and proposed that and CXCR3 may serve as novel drug targets to treat MG. CXCR3A and CXCR3B are involved in the chemotactic and vascular effects of CXCL4L1.

C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD183; CXCR3; GPR9

CXCR3

2833

P49682

Rat, Human

No cross-reactivity with other proteins

E.coli-derived human CXCR3 recombinant protein (Position: M1-L368) . Human CXCR3 shares 86% amino acid (aa) sequence identity with both mouse and rat CXCR3.

Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level) . .

Flow Cytometry

Atherosclerosis, Calcium Signaling, Cardiovascular, Chemokines, G Protein Signaling, Immunology, Innate Immunity, Signal Transduction, Signaling Pathway, Vascular Inflammation

Immunogen affinity purified.

Liquid

Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716) . Binds to CCL21. Probably promotes cell chemotaxis response. .

1. Trentin, L., Agostini, C., Facco, M., Piazza, F., Perin, A., Siviero, M., Gurrieri, C., Galvan, S., Adami, F., Zambello, R., Semenzato, G. The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis. J. Clin. Invest. 104: 115-121, 1999. 2. Frigerio, S., Junt, T., Lu, B., Gerard, C., Zumsteg, U., Hollander, G. A., Piali, L. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nature Med. 8: 1414-1420, 2002. 3. Feferman, T., Maiti, P. K., Berrih-Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., Souroujon, M. C. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. J. Immun. 174: 5324-5331, 2005. 4. Struyf, S., Salogni, L., Burdick, M. D., Vandercappellen, J., Gouwy, M., Noppen, S., Proost, P., Opdenakker, G., Parmentier, M., Gerard, C., Sozzani, S., Strieter, R. M., Van Damme, J. Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. Blood 117: 480-488, 2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

40660 MW

No cross reactivity with other proteins.

6

C-X-C chemokine receptor type 3

Isoform 1: Cell membrane ; Multi-pass membrane protein .

Belongs to the G-protein coupled receptor 1 family.

C-X-C chemokine receptor type 3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.