Anti-Cyclophiline B/PPIB Antibody Picoband® fluoro488 Vervoeging

Peptidyl-prolyl cis-trans isomerase B, also known as CYPB, is an enzyme that in humans is encoded by the PPIB gene. This gene is mapped to 15q22.31. The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.

Peptidyl-prolyl cis-trans isomerase B; PPIase B;5.2.1.8; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP; PPIB; CYPB

PPIB

5479

P23284

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Cyclophilin B, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Flow Cytometry

ER Proteins, Immunology, Protein Trafficking, Signal Transduction

Immunogen affinity purified.

Liquid

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1. Barnes, A. M., Cabral, W. A., Weis, M., Makareeva, E., Mertz, E. L., Leikin, S., Eyre, D., Trujillo, C., Marini, J. C. Absence of FKBP10 in recessive type XI osteogenesis imperfecta leads to diminished collagen cross-linking and reduced collagen deposition in extracellular matrix. Hum. Mutat. 33: 1589-1598, 2012. 2. van Dijk, F. S., Cobben, J. M., Pals, G. Osteogenesis imperfecta, normal collagen folding, and lack of cyclophilin B. (Letter) New Eng. J. Med. 362: 1940-1941, 2010. 3. Watashi, K., Ishii, N., Hijikata, M., Inoue, D., Murata, T., Miyanari, Y., Shimotohno, K.Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.Molec. Cell 19: 111-122, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

23743 MW

No cross reactivity with other proteins.

6

Peptidyl-prolyl cis-trans isomerase B

Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Peptidyl-prolyl cis-trans isomerase B

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.