Anti-CYP4F2 Antibody Picoband® APC-vervoeging

Cytochrome P450 4F2 is a protein that in humans is encoded by the CYP4F2 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.

CYP4F2; Cytochrome P450 4F2; EC 1.14.14.1; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; Arachidonic acid omega-hydroxylase; CYPIVF2; Cytochrome P450-LTB-omega; Docosahexaenoic acid omega-hydroxylase; EC 1.14.14.79; Leukotriene-B (4 20-monooxygenase 1; Leukotriene-B (4 omega-hydroxylase 1; EC 1.14.14.94; Phylloquinone omega-hydroxylase CYP4F2; EC 1.14.14.78

CYP4F2

8529

P78329

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human CYP4F2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Caldwell, M. D., Awad, T., Johnson, J. A., Gage, B. F., Falkowski, M., Gardina, P., Hubbard, J., Turpaz, Y., Langaee, T. Y., Eby, C., King, C. R., Brower, A., Schmelzer, J. R., Glurich, I., Vidaillet, H. J., Yale, S. H., Zhang, K. Q., Berg, R. L., Bumester, J. K. CYP4F2 genetic variant alters required warfarin dose. Blood 111: 4106-4112, 2008. 2. Kikuta, Y., Miyauchi, Y., Kusunose, E., Kusunose, M. Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene. DNA Cell Biol. 18: 723-730, 1999. 3. Ross, K. A., Bigham, A. W., Edwards, M., Gozdzik, A., Suarez-Kurtz, G., Parra, E. J. Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements. J. Hum. Genet. 55: 582-589, 2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

60 kDa

6

Cytochrome P450 family 4 subfamily F member 2

Cytochrome P450 4F2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.