Anti-Cystatine A/CSTA Antibody Picoband® 0,00647 Vervoeging

Cystatin A also called Stefin A is a protein that in humans is encoded by the CSTA gene. Cystatin A is a cysteine proteinase inhibitor that belongs to family 1 of the cystatin superpamily. This gene was assigned to human chromosome 3q21.1. This is an intracellular thiol proteinase inhibitor. Cystatin A plays an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. Stefins have been proposed as prognostic and diagnostic tools for cancer.

Cystatin-A; Cystatin-AS; Stefin-A; Cystatin-A, N-terminally processed; CSTA; STF1, STFA

CSTA

1475

P01040

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Cystatin A.

Expressed in the skin throughout the epidermis. .

Flow Cytometry

Apoptosis, Cancer, Caspases, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Intracellular, Invasion/Microenvironment, Signal Transduction

Immunogen affinity purified.

Liquid

This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. .

1. Blaydon, D. C., Nitoiu, D., Eckl, K.-M., Cabral, R. M., Bland, P., Hausser, I., van Heel, D. A., Rajpopat, S., Fischer, J., Oji, V., Zvulunov, A., Traupe, H., Hennies, H. C., Kelsell, D. P. Mutations in CSTA, encoding cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion. Am. J. Hum. Genet. 89: 564-571, 2011. 2. Samuelsson, L., Stiller, C., Friberg, C., Nilsson, C., Inerot, A., Wahlstrom, J.Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5. J. Invest. Derm. 122: 1399-1400, 2004. 3. Vasilopoulos, Y., Walters, J., Cork, M. J., Duff, G. W., Sagoo, G. S., Tazi-Ahnini, R.Association analysis of the skin barrier gene cystatin A at the PSORS5 locus in psoriatic patients: evidence for interaction between PSORS1 and PSORS5.Europ. J. Hum. Genet. 16: 1002-1009, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

11006 MW

No cross reactivity with other proteins.

6

Cystatin-A

Cytoplasm .

Belongs to the cystatin family.

Cystatin-A

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.