Anti-Cysteine protease ATG4C ATG4C Antilichaam

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) . ATG4C, also known as autophagin-3, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3) . Recent studies have shown that ATG4C and Beclin-1 are regulated by the microRNA miR-376b; overexpression of miR-376b led to decreased mRNA and protein levels, thereby blocking starvation and TOR inhibition-related autophagy (4) .

Boster Bio Anti-Cysteine protease ATG4C ATG4C Antibody (Catalog # A09728) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

APG4C, AUTL1, AUTL3, APG4-C, APG4C, Cysteine protease ATG4C, AUT-like 3 cysteine endopeptidase

ATG4C

Q96DT6

Human, Mouse, Rat

ATG4C antibody is human, mouse and rat reactive. ATG4C is predicted to not cross-react with other ATG4 proteins.

ATG4C antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ATG4C. The immunogen is located within the last 50 amino acids of ATG4C.

Highly expressed in skeletal muscle, heart, liver and testis.

ELISA, WB, IHC-P, IF

Autophagy

ATG4C antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity) . Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

ATG4C antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

https://www.bosterbio.com/msds?sku=A09728

52497 MW

Autophagy related 4C, cysteine peptidase

Cytoplasm .

Autophagy related 4C, cysteine peptidase

IgG

ATG4C antibody is supplied in PBS containing 0.02% sodium azide.