Anti-Cytochroom P450 3A4 CYP3A4 Monoklonale Antilichaam

Boster Bio Anti-Cytochrome P450 3A4 CYP3A4 Monoclonal Antibody catalog # M00339. Tested in WB, IHC, IP applications. This antibody reacts with Human.

Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A; BMP2; BMP2A

CYP3A4

1576

P08684

Human

A synthesized peptide derived from human Cytochrome P450 3A4 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.

Clone: ACDE-3

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

WB, IHC, IP

Cardiovascular, Cytochromes, Growth Factors/Hormones, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction

Affinity-chromatography

0.5mg/ml

Liquid

Induces cartilage and bone formation (PubMed:3201241) . Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451) . .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00339

44702 MW

32 kDa

Bone morphogenetic protein 2

Secreted.

P2X purinoceptor 1

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.