Anti-Cytokeratin 7 Alexa Fluor® 488

Cytokeratins are a subfamily of intermediate filaments and are characterized by remarkable biochemical diversity. They are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families.

Human

OTNII ovarian carcinoma cell line

Cytokeratin 7

OV-TL 12/30

IHC-P, IHC-F

0.1 mg/mL

Alexa Fluor® 488

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

*van Niekerk CC, Boerman OC, Ramaekers FC, Poels LG: Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas. Am J Pathol. 1991 Feb;138 (2) :455-63., URL: https://pubmed.ncbi.nlm.nih.gov/1992770/, *Torenbeek R, Lagendijk JH, Van Diest PJ, Bril H, van de Molengraft FJ, Meijer CJ: Value of a panel of antibodies to identify the primary origin of adenocarcinomas presenting as bladder carcinoma. Histopathology 1998 Jan;32 (1) :20-7. , URL: https://pubmed.ncbi.nlm.nih.gov/9522212/, *van Niekerk CC, Vooijs P, Casparie-van Velsen IJ, Poels LG: Differentiation margins of ovarian tumor pathology: First incidences of epithelial ovarian tumors monitored by marker antibodies. Cancer Detect Prev. 1997;21 (3) :247-57., URL: https://pubmed.ncbi.nlm.nih.gov/9167042/, *van Niekerk CC, Jap PH, Ramaekers FC, van de Molengraft F, Poels LG: Immunohistochemical demonstration of keratin 7 in routinely fixed paraffin-embedded human tissues. J Pathol. 1991 Oct;165 (2) :145-52. , URL: https://pubmed.ncbi.nlm.nih.gov/1720817/, *Ramaekers F, van Niekerk C, Poels L, Schaafsma E, Huijsmans A, Robben H, Schaart G, Vooijs P: Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas. Am J Pathol. 1990 Mar;136 (3) :641-55., URL: https://pubmed.ncbi.nlm.nih.gov/1690512/

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

The mouse monoclonal antibody OVTL12 recognizes cytokeratin 7, an intermediate filament protein.

Mouse IgG1 kappa