Anti-D-Dopachrome decarboxylase DDT Antibody Picoband® fluoro647 Vervoeging

DDT, D-dopachrome tautomerization, converts D-dopachrome into 5,6-dihydroxyindole. Northern blot analysis revealed that DDT was expressed as a 0.6-kb mRNA in all tissues tested, with the strongest expression in liver. The DDT gene in human and mouse is identical in exon structure to the MIF gene. Both genes have 2 introns that are located at equivalent positions, relative to a 2-fold repeat in protein structure.the genes for DDT and MIF are closely linked on human chromosome 22 and mouse chromosome 10.

D-dopachrome decarboxylase;4.1.1.84; D-dopachrome tautomerase; Phenylpyruvate tautomerase II; DDT

DDT

1652

P30046

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human DDT, different from the related mouse and rat sequence by two amino acids.

Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) .

1. Esumi, N., Budarf, M., Ciccarelli, L., Sellinger, B., Kozak, C. A., Wistow, G.Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF.Mammalian Genome 9: 753-757, 1998. 2. Nishihira, J., Fujinaga, M., Kuriyama, T., Suzuki, M., Sugimoto, H., Nakagawa, A., Tanaka, I., Sakai, M.Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation.Biochem. Biophys. Res. Commun. 243: 538-544, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

12712 MW

No cross reactivity with other proteins.

6

D-dopachrome decarboxylase

Cytoplasm .

Belongs to the intercrine alpha (chemokine CxC) family.

D-dopachrome decarboxylase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.