Anti-DAP Kinase 2/DAPK2 Antibody Picoband® fluoro550 Vervoeging

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene. This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.

Death-associated protein kinase 2; DAP kinase 2;2.7.11.1; DAP-kinase-related protein 1; DRP-1; DAPK2

DAPK2

23604

Q9UIK4

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human DAP Kinase 2, different from the related mouse and rat sequences by two amino acids.

Isoform 2 is expressed in embryonic stem cells (at protein level) . Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle. It is expressed abundantly in cells differentiated toward granulocytes and low in undifferentiated, normal and leukemic hematopoietic cells and monocytes/macrophages. .

Flow Cytometry

Apoptosis, Cell Biology, Intracellular, Kinases

Immunogen affinity purified.

Liquid

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation.

1. Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S (Jun 1999) . Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene 18 (23) : 3471–80. 2. Entrez Gene: DAPK2 death-associated protein kinase 2. 3. New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

42898 MW

No cross reactivity with other proteins.

6

Death-associated protein kinase 2

Cytoplasm. Cytoplasmic vesicle, autophagosome lumen.

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.

Death-associated protein kinase 2 (DAP kinase 2)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.