Anti-DBL Antibody Picoband® 31.0550 Vervoeging

The DBL proto-oncogene is a protein that in humans is encoded by the MCF2 gene. The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.

Protein phosphatase 1 regulatory subunit 14A;17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17; PPP1R14A; CPI17, PPP1INL

MCF2

4168

P10911

Human

No cross-reactivity with other proteins

E.coli-derived human DBL recombinant protein (Position: D42-Y925) .

Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. .

Flow Cytometry

Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Immunogen affinity purified.

Liquid

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

1. Anson, D. S., Blake, D. J., Winship, P. R., Birnbaum, D., Brownlee, G. G. Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients. EMBO J. 7: 2795-2799, 1988. 2. Eva, A., Aaronson, S. A. Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature 316: 273-275, 1985. 3. Eva, A., Vecchio, G., Rao, C. D., Tronick, S. R., Aaronson, S. A. The predicted DBL oncogene product defines a distinct class of transforming proteins. Proc. Nat. Acad. Sci. 85: 2061-2065, 1988.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

16693 MW

6

Protein phosphatase 1 regulatory subunit 14A

Cytoplasm .

Protein phosphatase 1 regulatory subunit 14A

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.