Anti-Desmoglein 2 Monoklonale Antilichaam

Boster Bio Anti-Desmoglein 2 Monoclonal Antibody catalog # M02035. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MLANA; MART1

DSG2

1829

Q14126

Human, Mouse, Rat

A synthesized peptide derived from human Desmoglein 2 Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Clone: AFBF-4

Expression is restricted to melanoma and melanocyte cell lines and retina.

WB, IHC, ICC, IF, Flow Cytometry

Cadherins, Cancer, Cardiovascular, Cell Adhesion, Cytoskeleton/ECM, Invasion/Microenvironment, Signal Transduction

Affinity-chromatography

0.5mg/ml

Liquid

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M02035

13157 MW

42 kDa

Melanoma antigen recognized by T-cells 1

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.