Anti-Dexras1/RASD1 Antibody Picoband® fluoro488 Vervoeging

Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein that in humans is encoded by the RASD1 gene on chromosome 17. This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Suppressor of cytokine signaling 5; SOCS-5; Cytokine-inducible SH2 protein 6; CIS-6; Cytokine-inducible SH2-containing protein 5; SOCS5; CIS6, CISH5, CISH6, KIAA0671

RASD1

51655

Q9Y272

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Dexras1/RASD1 recombinant protein (Position: M1-S281) .

Widely expressed. Expressed in TH1 but not TH2 cells.

Flow Cytometry

Cancer, Cell Biology, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

1. Cheng, H.-Y. M., Obrietan, K., Cain, S. W., Lee, B. Y., Agostino, P. V., Joza, N. A., Harrington, M. E., Ralph, M. R., Penninger, J. M. Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron 43: 715-728, 2004. 2. Fang, M., Jaffrey, S. R., Sawa, A., Ye, K., Luo, X., Snyder, S. H. Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron 28: 183-193, 2000. 3. Gross, M. B. Personal Communication. Baltimore, Md. 10/30/2017.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

80420 MW

6

Suppressor of cytokine signaling 5

Secreted.

Long-chain-fatty-acid--CoA ligase 3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.