Anti-DHX29 Antibody Picoband® fluoro488 Vervoeging

DExH-box helicase 29 (DHX29) is a 155 kDa protein that in humans is encoded by the DHX29 gene. This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.

Fascin-2; Retinal fascin; FSCN2

DHX29

54505

Q7Z478

Human

No cross-reactivity with other proteins.

E.coli-derived human DHX29 recombinant protein (Position: R56-K1343) .

Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.

Flow Cytometry

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Immunogen affinity purified.

Liquid

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 4/1/2009. 2. Pisareva, V. P., Pisarev, A. V., Komar, A. A., Hellen, C. U. T., Pestova, T. V. Translation initiation on mammalian mRNAs with structured 5-prime UTRs requires DExH-box protein DHX29. Cell 135: 1237-1250, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49229 MW

6

Fascin actin-bundling protein 2, retinal

Nucleus.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.