Anti-diclazurilZ1 Antibody Picoband® 0,00647 Vervoeging

Teashirt zinc finger homeobox 1 is a protein that in humans is encoded by the TSHZ1 gene. This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome.

Histone-lysine N-methyltransferase SETDB2; Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2; SETDB2; C13orf4; CLLD8; KMT1F

TSHZ1

10194

Q6ZSZ6

Human

No cross-reactivity with other proteins.

E.coli-derived human TSHZ1 recombinant protein (Position: K97-R800) .

Highly expressed in reproductive organs, such as testis, ovary and prostate.

Flow Cytometry

Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) . H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

1. Core, N., Caubit, X., Metchat, A., Boned, A., Djabali, M., Fasano, L. Tshz1 is required for axial skeleton, soft palate and middle ear development in mice. Dev. Biol. 308: 407-420, 2007. 2. Feenstra, I., Vissers, L. E. L. M., Pennings, R. J. E., Nillessen, W., Pfundt, R., Kunst, H. P., Admiraal, R. J., Veltman, J. A., van Ravenswaaij-Arts, C. M. A., Brunner, H. G., Cremers, C. W. R. J. Disruption of teashirt zinc finger homeobox 1 is associated with congenital aural atresia in humans. Am. J. Hum. Genet. 89: 813-819, 2011. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 1/12/2012.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

SET domain bifurcated histone lysine methyltransferase 2

Nucleus. Chromosome.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.