Anti-DLL4 Antibody Picoband® 31.0550 Vervoeging

Delta-like 4 is a protein that in humans is encoded by the DLL4 gene. It is mapped to 15q15.1. This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. And this gene plays an important role in promoting Th17 effector activity during mycobacterial challenge.

NF-kappa-B essential modulator; NEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier; IKBKG; FIP3, NEMO

DLL4

54567

Q9NR61

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human DLL4 recombinant protein (Position: S27-E678) .

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Flow Cytometry

Nuclear Signaling Pathways, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathway, TLR Signaling, Vascular Inflammation

Immunogen affinity purified.

Liquid

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. .

1. Entrez Gene: DLL4 delta-like 4 (Drosophila) . 2. Dorsch M, Zheng G, Yowe D, et al. (2002) . Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. Blood. 100 (6) : 2046–55. 3. Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL (Jul 2000) . Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev. 14 (11) : 1313–8.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

48198 MW

6

NF-kappa-B essential modulator

Cytoplasm . Nucleus . Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.