Anti-DNAJB6 Antibody Picoband® APC-vervoeging

This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.

DNAJB6; HSJ2; MRJ; MSJ1; DnaJ homolog subfamily B member 6; HHDJ1; Heat shock protein J2; HSJ-2; MRJ; MSJ-1

DNAJB6

10049

O75190

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human DNAJB6.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Bengoechea, R., Pittman, S. K., Tuck, E. P., True, H. L., Weihl, C. C. Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D. Hum. Molec. Genet. 24: 6588-6602, 2015. 2. Chuang, J.-Z., Zhou, H., Zhu, M., Li, S.-H., Li, X.-J., Sung, C.-H. Characterization of a brain-enriched chaperone, MRJ, that inhibits huntingtin aggregation and toxicity independently. J. Biol. Chem. 277: 19831-19838, 2002. 3. Couthouis, J., Raphael, A. R., Siskind, C., Findlay, A. R., Buenrostro, J. D., Greenleaf, W. J., Vogel, H., Day, J. W., Flanigan, K. M., Gitler, A. D. Exome sequencing identifies a DNAJB6 mutation in a family with dominantly-inherited limb-girdle muscular dystrophy. Neuromusc. Disord. 24: 431-435, 2014.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

36 kDa

6

DnaJ heat shock protein family (Hsp40) member B6

DnaJ homolog subfamily B member 6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.