Anti-DNMT3B Antibody Picoband® fluoro550 Vervoeging

DNA (cytosine-5-) -methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Copper chaperone for superoxide dismutase; Superoxide dismutase copper chaperone; CCS

DNMT3B

1789

P50570

Human, Mouse, Rat, Monkey

No cross-reactivity with other proteins

E.coli-derived human DNMT3B recombinant protein (Position: E271-E853) .

Ubiquitous.

Flow Cytometry

Cancer, Cardiovascular, Metabolism, Neuroscience, Neurotransmission, Plasma Membrane, Potassium Channels, Receptors / Channels, Signal Transduction

Immunogen affinity purified.

Liquid

Delivers copper to copper zinc superoxide dismutase (SOD1) .

1. Balada, E., Ordi-Ros, J., Serrano-Acedo, S., Martinez-Lostao, L., Rosa-Leyva, M., Vilardell-Tarres, M. Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus. Immunology 124: 339-347, 2008. 2. Barau, J., Teissandier, A., Zamudio, N., Roy, S., Nalesso, V., Herault, Y., Guillou, F., Bourc'his, D. The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science 354: 909-912, 2016. 3. Beaulieu, N., Morin, S., Chute, I. C., Robert, M.-F., Nguyen, H., MacLeod, A. R. An essential role for DNA methyltransferase DNMT3B in cancer cell survival. J. Biol. Chem. 277: 28176-28181, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

29041 MW

6

Copper chaperone for superoxide dismutase

Cytoplasm .

Copper chaperone for superoxide dismutase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.