Anti-DOCK180/DOCK1 Antibody Picoband®

Dock180, (Dedicator of cytokinesis) also known as DOCK1, is a large (~180 kDa) protein involved in intracellular signalling networks. This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants.

Boster Bio Anti-DOCK180/DOCK1 Antibody Picoband® catalog # A03440-2. Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Tumor necrosis factor-inducible gene 6 protein; Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6; TNFAIP6; TSG6

DOCK1

1793

Q14185

Human

No cross-reactivity with other proteins.

E.coli-derived human DOCK180/DOCK1 recombinant protein (Position: S100-T1732) .

Found in the synovial fluid of patients with rheumatoid arthritis. .

ELISA, Flow Cytometry, IF, IHC, WB

Cancer, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Immunology, Innate Immunity, Invasion/Microenvironment, Macrophage/Inflammation, Signal Transduction

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

1. Cote, J.-F., Vuori, K. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell Sci. 115: 4901-4913, 2002. 2. Gross, M. B. Personal Communication. Baltimore, Md. 8/31/2016. 3. Hasegawa, H., Kiyokawa, E., Tanaka, S., Nagashima, K., Gotoh, N., Shibuya, M., Kurata, T., Matsuda, M. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the membrane. Molec. Cell Biol. 16: 1770-176, 1996.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A03440-2

31203 MW

215 kDa

6

Tumor necrosis factor-inducible gene 6 protein

Late endosome membrane. Peripheral membrane protein. Prevacuolar compartment membrane.

Tumor necrosis factor-inducible gene 6 protein

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.