Anti-DOCK180/DOCK1 Antibody Picoband® fluoro550 Vervoeging

Dock180, (Dedicator of cytokinesis) also known as DOCK1, is a large (~180 kDa) protein involved in intracellular signalling networks. This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants.

Tumor necrosis factor-inducible gene 6 protein; Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6; TNFAIP6; TSG6

DOCK1

1793

Q14185

Human

No cross-reactivity with other proteins.

E.coli-derived human DOCK180/DOCK1 recombinant protein (Position: S100-T1732) .

Found in the synovial fluid of patients with rheumatoid arthritis. .

Flow Cytometry

Cancer, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Immunology, Innate Immunity, Invasion/Microenvironment, Macrophage/Inflammation, Signal Transduction

Immunogen affinity purified.

Liquid

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

1. Cote, J.-F., Vuori, K. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell Sci. 115: 4901-4913, 2002. 2. Gross, M. B. Personal Communication. Baltimore, Md. 8/31/2016. 3. Hasegawa, H., Kiyokawa, E., Tanaka, S., Nagashima, K., Gotoh, N., Shibuya, M., Kurata, T., Matsuda, M. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the membrane. Molec. Cell Biol. 16: 1770-176, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

31203 MW

6

Tumor necrosis factor-inducible gene 6 protein

Late endosome membrane. Peripheral membrane protein. Prevacuolar compartment membrane.

Tumor necrosis factor-inducible gene 6 protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.