Anti-DOCK8 Antibody Picoband® 0,00647 Vervoeging

This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

DOCK8; Dedicator of cytokinesis protein 8

DOCK8

81704

Q8NF50

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human DOCK8 recombinant protein (Position: M1-S2099) . Human DOCK8 shares 91.8% amino acid (aa) sequence identity with mouse DOCK8.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Griggs, B. L., Ladd, S., Saul, R. A., DuPont, B. R., Srivastava, A. K. Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities. Genomics 91: 195-202, 2008. 2. MacDermot, K. D., Hulten, M. Female with hypohidrotic ectodermal dysplasia and de novo (X;9) translocation: clinical documentation of the AnLy cell line case. Hum. Genet. 84: 577-579, 1990. 3. Pillay, B. A., Fusaro, M., Gray, P. E., Statham, A. L., Burnett, L., Bezrodnik, L., Kane, A., Tong, W., Abdo, C., Winter, S., Chevalier, S., Levy, R., and 18 others. Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency. J. Clin. Invest. 131: e142434, 2021.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

239 kDa

6

Dedicator of cytokinesis 8

Dedicator of cytokinesis protein 8

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.