Anti-DOPA decarboxylase/DDC Antibody Picoband®

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) . AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Boster Bio Anti-DOPA decarboxylase/DDC Antibody Picoband® catalog # A01374-2. Tested in WB, IHC, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

DDC; AADC; Aromatic-L-amino-acid decarboxylase; AADC; EC 4.1.1.28; DOPA decarboxylase; DDC

DDC

1644

P20711

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human DOPA decarboxylase/DDC, which shares 76% amino acid (aa) sequence identity with both mouse and rat DOPA decarboxylase/DDC.

WB, IHC, IP, Flow Cytometry

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

1. Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., Blakely, R. D., Deneris, E. S., Levitt, P. A transient placental source of serotonin for the fetal forebrain. Nature 472: 347-350, 2011. 2. Brun, L., Ngu, L. H., Keng, W. T., Ch'ng, G. S., Choy, Y. S., Hwu, W. L., Lee, W. T., Willemsen, M. A. A. P., Verbeek, M. M., Wassenberg, T., Regal, L., Orcesi, S., and 13 others. Clinical and biochemical features of aromatic L-amino acid decarboxylase deficiency. Neurology 75: 64-71, 2010. Note: Erratum: Neurology 75: 576 only, 2010. 3. Bruneau, G., Gross, M.-S., Krieger, M., Bernheim, A., Thibault, J., Nguyen, V. C. Preparation of a human DOPA decarboxylase cDNA probe by PCR and its assignment to chromosome 7. Ann. Genet. 33: 208-213, 1990.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A01374-2

54 kDa

50 kDa

6

Dopa decarboxylase

Aromatic-L-amino-acid decarboxylase

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.