Anti-Dopaminereceptor D3/DRD3 Antibody Picoband® fluoro488 Vervoeging

DRD3 is a dopamine receptor that differs in its pharmacology and signaling system from the D1 and D2 receptors and represents both an autoreceptor and a postsynaptic receptor. DRD3 is localized to limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. The DRD3 gene, which is mapped to chromosome 3, is like the DRD2 gene but unlike most other members of this superfamily and it contains introns, 5 in number. The position of 2 of the introns corresponds to that of introns in DRD2. The D3 receptor appeared to mediate some of the effects of antipsychotic drugs and drugs used in the treatment of Parkinson disease, which were previously though to interact only with D2 receptors.

D (3) dopamine receptor; Dopamine D3 receptor; DRD3

DRD3

1814

P35462

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Dopamine Receptor D3, different from the related rat and mouse sequences by two amino acids.

Brain.

Flow Cytometry

Neuroscience, Neurotransmission, Receptors / Channels

Immunogen affinity purified.

Liquid

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. .

1. Sokoloff, P., Giros, B., Martres, M.-P., Bouthenet, M.-L., Schwartz, J.-C.Molecular cloning and characterization of a novel dopamine receptor (D-3) as a target for neuroleptics.Nature 347: 146-151, 1990. 2. Le Coniat, M., Sokoloff, P., Hillion, J., Martres, M.-P., Giros, B., Pilon, C., Schwartz, J.-C., Berger, R.Chromosomal localization of the human D-3 dopamine receptor gene.Hum. Genet. 87: 618-620, 1991. 3. Sokoloff, P., Giros, B., Martres, M.-P., Bouthenet, M.-L., Schwartz, J.-C.Molecular cloning and characterization of a novel dopamine receptor (D-3) as a target for neuroleptics.Nature 347: 146-151, 1990.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

44 kDa

No cross reactivity with other proteins.

6

D (3) dopamine receptor

Cell membrane ; Multi-pass membrane protein . Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes) . DRD3 and GRK4 co- localize in lipid rafts of renal proximal tubule cells.

Belongs to the G-protein coupled receptor 1 family.

D (3) dopamine receptor

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.