Anti-DVL2 Antilichaam Picoband® fluoro594 Vervoeging

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene. This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

DVL2

132299

O14641

Human, Mouse, Rat

E.coli-derived human DVL2 recombinant protein (Position: L89-Y576) . Human DVL2 shares 97.3% amino acid (aa) sequence identity with mouse DVL2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Capelluto, D. G. S., Kutateladze, T. G., Habas, R., Finkielstein, C. V., He, X., Overduin, M. The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. Nature 419: 726-729, 2002. 2. Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L. A., Miller, W. E., Caron, M. G., Barak, L. S., Nusse, R., Lefkowitz, R. J. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of frizzled 4. Science 301: 1391-1394, 2003. 3. Greco, T. L., Sussman, D. J., Camper, S. A. Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. Mammalian Genome 7: 475-476, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

79 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.