Anti-Dynamin 2/DNM2 Antibody Picoband® 310647 Vervoeging

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene. Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.

Dynamin-2; DNM2; DYN2

DNM2

1785

P50570

Human

No cross-reactivity with other proteins.

E.coli-derived human Dynamin 2/DNM2 recombinant protein (Position: N498-R785) .

Ubiquitously expressed.

Flow Cytometry

Protein Trafficking, Second Messenger, Secretory Vesicles, Signal Transduction, Vesicle Transport

Immunogen affinity purified.

Liquid

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity) . Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685) . Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity) .

1. Entrez Gene: DNM2 dynamin 2. 2. Diatloff-Zito C, Gordon AJ, Duchaud E, Merlin G (Nov 1995) . Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family. Gene. 163 (2) : 301–6. 3. Klocke R, Augustin A, Ronsiek M, Stief A, van der Putten H, Jockusch H (Jul 1997) . Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively. Genomics. 41 (2) : 290–2.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Dynamin 2

Cytoplasm. Cytoplasm, cytoskeleton. Cell junction.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.