Anti-ECRG4 C2orf40 Antilichaam

The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues.. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.

Boster Bio Anti-ECRG4 C2orf40 Antibody (Catalog # A10864) . Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat.

ECRG4, ECRG4, UNQ761/PRO1508, Augurin, Esophageal cancer-related gene 4 protein

C2ORF40

Q9H1Z8

Human, Mouse, Rat

ECRG4 antibody is predicted to not cross-react with other ECRG family members.

ECRG4 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human ECRG4. The immunogen is located within the last 50 amino acids of ECRG4.

ELISA, WB, ICC

Cancer, Cell Cycle

ECRG4 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.

ECRG4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A10864

17183 MW

Chromosome 2 open reading frame 40

Secreted

Bovine

Chromosome 2 open reading frame 40

IgG

ECRG4 Antibody is supplied in PBS containing 0.02% sodium azide.