Anti-EDEM1 Antibody Picoband® 0,00647 Vervoeging

Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Involved in positive regulation of retrograde protein transport, ER to cytosol; protein targeting to ER; and proteolysis involved in protein catabolic process. Located in aggresome and endoplasmic reticulum quality control compartment.

EDEM1; EDEM; KIAA0212; ER degradation-enhancing alpha-mannosidase-like protein 1

EDEM1

9695

Q92611

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human EDEM1 recombinant protein (Position: P124-I657) . Human EDEM1 shares 96.6% amino acid (aa) sequence identity with mouse EDEM1.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Hosokawa, N., Wada, I., Hasegawa, K., Yorihuzi, T., Tremblay, L. O., Herscovics, A., Nagata, K. A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep. 2: 415-422, 2001. 2. Molinari, M., Calanca, V., Galli, C., Lucca, P., Paganetti, P. Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. Science 299: 1397-1400, 2003. 3. Nagase, T., Seki, N., Ishikawa, K., Ohira, M., Kawarabayasi, Y., Ohara, O., Tanaka, A., Kotani, H., Miyajima, N., Nomura, N. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 3: 321-329, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

74 kDa

6

ER degradation enhancing alpha-mannosidase like protein 1

ER degradation-enhancing alpha-mannosidase-like protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.