Anti-EDEM1 Antibody Picoband® Biotin Conjugated

Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Involved in positive regulation of retrograde protein transport, ER to cytosol; protein targeting to ER; and proteolysis involved in protein catabolic process. Located in aggresome and endoplasmic reticulum quality control compartment.

EDEM1; EDEM; KIAA0212; ER degradation-enhancing alpha-mannosidase-like protein 1

EDEM1

9695

Q92611

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human EDEM1 recombinant protein (Position: P124-I657) . Human EDEM1 shares 96.6% amino acid (aa) sequence identity with mouse EDEM1.

WB, IHC, ELISA

Immunogen affinity purified.

Liquid

1. Hosokawa, N., Wada, I., Hasegawa, K., Yorihuzi, T., Tremblay, L. O., Herscovics, A., Nagata, K. A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep. 2: 415-422, 2001. 2. Molinari, M., Calanca, V., Galli, C., Lucca, P., Paganetti, P. Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. Science 299: 1397-1400, 2003. 3. Nagase, T., Seki, N., Ishikawa, K., Ohira, M., Kawarabayasi, Y., Ohara, O., Tanaka, A., Kotani, H., Miyajima, N., Nomura, N. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 3: 321-329, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

74 kDa

ER degradation enhancing alpha-mannosidase like protein 1

ER degradation-enhancing alpha-mannosidase-like protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.