Anti-Eg5/KIF11 Antibody Picoband® fluoro647 Vervoeging

Kinesin-like protein KIF11 is a molecular motor protein that is essential in mitosis. In humans it is coded for by the gene KIF11. This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein subunit of complex II; Fp; SDHA; SDH2; SDHF

KIF11

3832

P52732

Human

No cross-reactivity with other proteins.

E.coli-derived human Eg5/KIF11 recombinant protein (Position: K17-Q716) .

Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.

Flow Cytometry

Amino Acid Metabolism, Amino Acids, Cancer, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) . Can act as a tumor suppressor.

1. Bartoli, K. M., Jakovljevic, J., Woolford, J. L., Jr., Saunders, W. S. Kinesin molecular motor Eg5 functions during polypeptide synthesis. Molec. Biol. Cell 22: 3420-3430, 2011. 2. Birtel, J., Gliem, M., Mangold, E., Tebbe, L., Spier, I., Muller, P. L., Holz, F. G., Neuhaus, C., Wolfrum, U., Bolz, H. J., Issa, P. C. Novel insights into the phenotypical spectrum of KIF11-associated retinopathy, including a new form of retinal ciliopathy. Invest. Ophthal. Vis. Sci. 58: 3950-3959, 2017. 3. Blangy, A., Lane, H. A., d'Herin, P., Harper, M., Kress, M., Nigg, E. A. Phosphorylation by p34 (cdc2) regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83: 1159-1169, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Succinate dehydrogenase complex flavoprotein subunit A

Mitochondrion inner membrane. Peripheral membrane protein. Matrix side.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.