Anti-EGFR (L858R mutatie) Konijn Monoklonale Antilichaam

Boster Bio Anti-EGFR (L858R mutation) Rabbit Monoclonal Antibody catalog # M00023-5. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Signal transducer and activator of transcription 3; Acute-phase response factor; STAT3; APRF

EGFR

1956

P00533

Human

A synthesized peptide derived from human EGFR (L858R mutation)

Clone: 20E88

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

WB, IHC, ICC, IF

Cancer, Growth Factors/Hormones, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tumor Biomarkers, Tyrosine Kinases

Affinity-chromatography

0.5mg/ml

Liquid

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6) - responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity) . .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00023-5

88068 MW

175 kDa

Signal transducer and activator of transcription 3

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.

P2X purinoceptor 1

IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.