Anti-EGR2 Antibody Picoband® 31.0550 Vervoeging

Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS) . Multiple transcript variants encoding two different isoforms have been found for this gene.

EGR2

1959

P11161

Human, Mouse, Rat

E.coli-derived human EGR2 recombinant protein (Position: M1-R257) . Human EGR2 shares 90.7% amino acid (aa) sequence identity with both mouse and rat EGR2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Boerkoel, C. F., Takashima, H., Bacino, C. A., Daentl, D., Lupski, J. R. EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy. Neurogenetics 3: 153-157, 2001. 2. Chavrier, P., Janssen-Timmen, U., Mattei, M.-G., Zerial, M., Bravo, R., Charnay, P. Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos. Molec. Cell. Biol. 9: 787-797, 1989. 3. Chung, K. W., Sunwoo, I. N., Kim, S. M., Park, K. D., Kim, W.-K., Kim, T. S., Koo, H., Cho, M., Lee, J., Choi, B. O. Two missense mutations of EGR2 R359W and GJB1 V136A in a Charcot-Marie-Tooth disease family. Neurogenetics 6: 159-163, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

50,45 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.