Anti-EGR2 Antilichaam Picoband® fluoro594 Vervoeging

Early growth response protein 2, also called EGR2 or E3 SUMO-protein ligase EGR2, is a protein that in humans is encoded by the EGR2 gene. This gene is mapped to 10q21.3. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS) . E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.

E3 SUMO-protein ligase EGR2;6.3.2.-; AT591; Early growth response protein 2; EGR-2; Zinc finger protein Krox-20; EGR2; KROX20

EGR2

1959

P11161

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human EGR2, different from the related rat and mouse sequences by one amino acid.

In eosinophils as well as trace amounts in neutrophils and monocytes.

Flow Cytometry

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Neurodegenerative Disease, Neurology Process, Neuroscience, Transcription, Zinc Finger

Immunogen affinity purified.

Liquid

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. .

1. Chung, K. W., Sunwoo, I. N., Kim, S. M., Park, K. D., Kim, W.-K., Kim, T. S., Koo, H., Cho, M., Lee, J., Choi, B. O. Two missense mutations of EGR2 R359W and GJB1 V136A in a Charcot-Marie-Tooth disease family. Neurogenetics 6: 159-163, 2005. 2. Szigeti, K., Wiszniewski, W., Saifi, G. M., Sherman, D. L., Sule, N., Adesina, A. M., Mancias, P., Papasozomenos, S. C., Miller, G., Keppen, L., Daentl, D., Brophy, P. J., Lupski, J. R. Functional, histopathologic and natural history study of neuropathy associated with EGR2 mutations. Neurogenetics 8: 257-262, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

50302 MW

No cross reactivity with other proteins.

6

E3 SUMO-protein ligase EGR2

Nucleus.

Belongs to the EGR C2H2-type zinc-finger protein family.

E3 SUMO-protein ligase EGR2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.