Anti-EIF4ENIF1 Antibody Picoband® fluoro647 Vervoeging

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene. The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene.

Spermine oxidase; Polyamine oxidase 1; PAO-1; PAOh1; Smox; Smo

EIF4ENIF1

56478

Q9NRA8

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human EIF4ENIF1 recombinant protein (Position: D13-Q985) .

Widely expressed. Isoform 1 and isoform 2 are expressed at higher level in brain and skeletal muscle. Isoform 7 is found in brain and spleen, isoform 10 is widely expressed but found at lower level in heart, kidney, liver and lung.

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N1-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.

1. Dostie, J., Ferraiuolo, M., Pause, A., Adam, S. A., Sonenberg, N. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5-prime cap-binding protein, eIF4E. EMBO J. 19: 3142-3156, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

48608 MW

6

Spermine oxidase

Cytoplasm. Nucleus. Cytoplasm.

Serine protease HTRA3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.