Anti-elastine-ELN-antilichaam (monoclonaal, BA-4)

Elastin is a major structural protein of tissues such as aorta, which must expand rapidly and recover completely. Elastin chains are cross-linked together into an extensible 3D network. It is a molecular determinant of late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in elastin are a cause of autosomal dominant cutis laxa.

Boster Bio Anti-Elastin ELN Antibody (Monoclonal, BA-4) catalog # MA1038. Tested in IHC applications. This antibody reacts with Bovine, Human.

Elastin; Tropoelastin; ELN

ELN

Human (2006), Mouse (13717), Rat (25043)

P15502

Bovine, Human

No cross-reactivity with other proteins

Bovine alpha-elastin.

Clone: BA-4

Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level) . Also expressed in the large arteries, lung and skin. .

IHC

Cardiovascular, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction, Vasculature

Ascites

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Lyophilized

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity) . .

1. Rosenbloom, J. : Personal Communication. Philadelphia, Pa., 4/1984 2. Urban, Z.; Riazi, S.; Seidl, T. L.; Katahira, J.; Smoot, L. B.; Chitayat, D.; Boyd, C. D.; Hinek, A. : Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome. Am. J. Hum. Genet. 71: 30-44, 2002. 3. Uitto, J.; Christiano, A. M.; Kahari, V.-M.; Bashir, M. M.; Rosenbloom, J. : Molecular biology and pathology of human elastin. Biochem. Soc. Trans. 19: 824-829, 1991.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=MA1038

68469 MW

426 kDa

No cross reactivity with other proteins.

Elastin

Secreted, extracellular space, extracellular matrix . Extracellular matrix of elastic fibers. .

Belongs to the elastin family.

Elastin

Mouse IgG1

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.