Anti-ELK1 Antibody Picoband® fluoro550 Vervoeging

ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.

Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD126; IL6R

ELK1

2002

P19419

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human ELK1 recombinant protein (Position: S4-K52) .

Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Flow Cytometry

Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Interleukins, Lymphoid, Myeloid, Stem Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Liquid

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

1. Barrett, L. E., Van Bockstaele, E. J., Sul, J. Y., Takano, H., Haydon, P. G., Eberwine, J. H. Elk-1 associates with the mitochondrial permeability transition pore complex in neurons. Proc. Nat. Acad. Sci. 103: 5155-5160, 2006. 2. Giovane, A., Sobieszczuk, P., Mignon, C., Mattei, M.-G., Wasylyk, B. Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes. Genomics 29: 769-772, 1995. 3. Janz, M., Lehmann, U., Olde Weghuis, D., de Leeuw, B., Geurts van Kessel, A., Gilgenkrantz, S., Hipskind, R. A., Nordheim, A. Refined mapping of the human Ets-related gene Elk-1 to Xp11.2-p11.4, distal to the OATL1 region. Hum. Genet. 94: 442-444, 1994.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

51548 MW

6

Interleukin-6 receptor subunit alpha

Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein.

Keratin, type II cytoskeletal 8

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.