Anti-Elongin-C/ELOC Antilichaam Picoband® 31.0550 Vervoeging

Elongin C is a protein that in humans is encoded by the ELOC gene. This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

Lymphocyte antigen 6A-2/6E-1; Ly-6A.2/Ly-6E.1; Stem cell antigen 1; SCA-1; T-cell-activating protein; TAP; Ly6a; Ly6

ELOC

6921

Q15369

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Elongin-C/ELOC recombinant protein (Position: M1-C112) .

Widely expressed. .

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

T-cell activation.

1. Aso, T., Lane, W. S., Conaway, J. W., Conaway, R. C. Elongin (SIII) : a multisubunit regulator of elongation by RNA polymerase II. Science 269: 1439-1443, 1995. 2. Demetrick, D. J., Zhang, H., Beach, D. H. Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2) . Cytogenet. Cell Genet. 73: 104-107, 1996. 3. Duan, D. R., Pause, A., Burgess, W. H., Aso, T., Chen, D. Y. T., Garrett, K. P., Conaway, R. C., Conaway, J. W., Linehan, W. M., Klausner, R. D. Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 269: 1402-1406, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

14377 MW

6

Lymphocyte antigen 6A-2/6E-1

Cell membrane; Lipid-anchor, GPI-anchor.

Lymphocyte antigen 6A-2/6E-1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.