Anti-Eotaxine 3/CCL26 Antibody Picoband® fluoro488 Vervoeging

Eotaxin-3 is a small cytokine belonging to the CC chemokine family that is also called CCL26, Chemokine (C-C motif) ligand 26. Chemokines play pivotal roles in health and disease by controlling migration and tissue localization of specific types of cells expressing their cognate receptors. Eotaxin-3 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4. This gene for chemokine is located on human chromosome 7. Eotaxin-3 induced migration of eosinophils and basophils only at a 10-fold higher concentration than eotaxin.

C-C motif chemokine 26; CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha; MIP-4-alpha; Small-inducible cytokine A26; Thymic stroma chemokine-1; TSC-1; CCL26; SCYA26; UNQ216/PRO242

CCL26

10344

Q9Y258

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Eotaxin 3.

Ubiquitously expressed at low levels in various tissues including heart and ovary.

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Chemotactic for eosinophils and basophils. Binds to CCR3.

1. Guo, R.-F., Ward, P. A., Hu, S.-M., McDuffie, J. E., Huber-Lang, M., Shi, M. M.Molecular cloning and characterization of a novel human CC chemokine, SCYA26.Genomics 58: 313-317, 1999. 2. Kitaura, M., Suzuki, N., Imai, T., Takagi, S., Suzuki, R., Nakajima, T., Hirai, K., Nomiyama, H., Yoshie, O.Molecular cloning of a novel human CC chemokine (eotaxin-3) that is a functional ligand of CC chemokine receptor 3.J. Biol. Chem. 274: 27975-27980, 1999. 3. Nakayama, T., Watanabe, Y., Oiso, N., Higuchi, T., Shigeta, A., Mizuguchi, N., Katou, F., Hashimoto, K., Kawada, A., Yoshie, O.Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1.J. Immun. 185: 6472-6479, 2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

10648 MW

No cross reactivity with other proteins.

6

C-C motif chemokine 26

Secreted.

Belongs to the intercrine beta (chemokine CC) family.

C-C motif chemokine 26

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.