Anti-Eph receptor A1/EPHA1 Antibody Picoband® fluoro488 Vervoeging

EPHA1, EPH receptor A1, is a protein that in humans is encoded by the EPHA1 gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The EPHA1 gene is mapped to 7q34-q35. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.

Ephrin type-A receptor 1; hEpha1;2.7.10.1; EPH tyrosine kinase; EPH tyrosine kinase 1; Erythropoietin-producing hepatoma receptor; Tyrosine-protein kinase receptor EPH; EPHA1; EPH, EPHT, EPHT1

EPHA1

2041

P21709

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Eph receptor A1, identical to the related rat and mouse sequences.

Overexpressed in several carcinomas.

Flow Cytometry

Neuroscience, Neurotransmission, Protein Phosphorylation, Receptor Tyrosine Kinases, Receptors / Channels, Signal Transduction, Tyrosine Kinases

Immunogen affinity purified.

Liquid

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent biional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. .

1. Hattori, M., Osterfield, M., Flanagan, J. G.Regulated cleavage of a contact-mediated axon repellent.Science 289: 1360-1365, 2000. 2. Torii, M., Hashimoto-Torii, K., Levitt, P., Rakic, P.Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling.Nature 461: 524-528, 2009. Note: Erratum: Nature 462: 674 only, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

108127 MW

No cross reactivity with other proteins.

6

Ephrin type-A receptor 1

Cell membrane ; Single-pass type I membrane protein .

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Ephrin type-A receptor 1 (hEpha1)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.