Anti-Eph receptor A3/EPHA3 Antibody Picoband® fluoro647 Vervoeging

Ephrin Receptor EphA3, is also known as human embryo kinase (HEK) or Eph-like tyrosine kinase1 (ETK1) . Kinases that phosphorylate proteins on tyrosine residues (protein tyrosine kinases; PTKs), such as EPHA3, form a structurally related group of molecules that exhibit functional diversity. Genetic alterations that lead to the inappropriate activation or expression of PTKs may be oncogenic. Many growth factor receptors are PTKs, e.g., the receptors for epidermal growth factor (EGFR), platelet-derived growth factor (PDGFR1; PDGFR2), colony-stimulating factor-1 (CSF1R), and stem cell growth factor. The EPHA3 gene is mapped to 3p11.2. Sequence comparison with other PTKs showed a high degree of homology with members of the EPH and ELK (EPHB1) families of receptor tyrosine kinases. Within axial nerves, establishment of discrete afferent and efferent pathways depends on coordinate signaling between coextending sensory and motor projections.

Tumor necrosis factor receptor superfamily member 13C; B-cell maturation defect; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268; Tnfrsf13c; Baffr; Bcmd; Br3

EPHA3

2042

P29320

Human

No cross-reactivity with other proteins.

E.coli-derived human Eph receptor A3/EPHA3 recombinant protein (Position: D59-A514) .

Highly expressed in spleen and testis; detected at lower levels in lung and thymus.

Flow Cytometry

Growth Factors/Hormones, Signal Transduction

Immunogen affinity purified.

Liquid

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

1. Boyd, A. W., Ward, L. D., Wicks, I. P., Simpson, R. J., Salvaris, E., Wilks, A., Welch, K., Loudovaris, M., Rockman, S., Busmanis, I. Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line. J. Biol. Chem. 267: 3262-3267, 1992. 2. Fox, G. M., Holst, P. L., Chute, H. T., Lindberg, R. A., Janssen, A. M., Basu, R., Welcher, A. A. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. Oncogene 10: 897-905, 1995. 3. Gallarda, B. W., Bonanomi, D., Mueller, D., Brown, A., Alaynick, W. A., Andrews S. E., Lemke, G., Pfaff, S. L., Marquardt, T. Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling. Science 320: 233-236, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Tumor necrosis factor receptor superfamily, member 13c

Membrane; Single-pass type III membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.