Anti-EphA2 (Extracellulair gebied) M049 Antilichaam

The Eph family of receptor tyrosine kinases and their Ephrin ligands are important for cell positioning and morphogenesis during development. Eph receptors are classified into 10 EphA and 6 EphB receptors, which preferentially bind to the type A and type B ephrins, respectively. Ephrin type-A receptor 2 (EphA2), also known as epithelial cell kinase (Eck), binds the ephrin A1 (EFNA1) ligand, and has roles in neuronal development and repair, as well as carcinogenesis. EphA2 receptor has an N-terminal ligand-binding domain followed by a cysteine-rich domain with an epidermal growth factor-like motif and two fibronectin type-III repeats in the extracellular region, and a sterile alpha motif (SAM), and a PDZ domain-binding motif in the intracellular region. EphA2 is expressed in many types of cancers, including breast, colon, bladder, gastric, and glioblastoma. In bladder cancers, EphA2 may be activated by progranulin leading to phosphorylation at Ser-897 and bladder tumorigenesis. EphA2 may be an important therapeutic target and biomarker for several types of cancer.

Our EphA2 (Extracellular region) M049 Antibody mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human EphA2 (Extracellular region) M049 Antibody and is protein g purified. It is great for use in ELISA, WB (Nat), ICC, IP.

Our EphA2 (Extracellular region) M049 Antibody mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human EphA2 (Extracellular region) M049 Antibody and is Protein G purified. It is great for use in WB (Nat), ICC, IP.

EphA2, P29317, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Ephrin type-A receptor 2

EPHA2

P29317

Human

Clone (M049) was generated from a recombinant protein that included the extracellular region of human EphA2 protein.

EphA2 (Extracellular region) M049 Antibody

M049

Unconjugated

ELISA, WB (Nat), ICC, IP

Cardiovascular, Cell Signaling, Kinase Signaling, Oncoproteins

Protein G Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

GOmAb

125

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein G purified culture supernatant.

1:1000

1:100

Clone M049 mouse monoclonal antibody detects a 125kDa* protein on SDS-PAGE "Native" immunoblots of human NCI-H2052 and MDA-MB-231 carcinomas, as well as the EphA2 C-terminal 60 kDa fragment in human A431 and A549. The antibody detects native EphA2, as well as aldehyde-fixed EphA2. The antibody works for Native western blot, immunoprecipitation, immunocytochemistry, and ELISA capture.

1:100

Western blots performed on each lot.

Mouse

Liquid

IgG1

Human

Quality Control: WB

AB_3068420