Anti-EPLIN/LIMA1 Antibody Picoband® fluoro550 Vervoeging

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene. This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated.

Zinc finger protein Helios; Ikaros family zinc finger protein 2; IKZF2; HELIOS, ZNFN1A2

LIMA1

51474

Q9UHB6

Human

No cross-reactivity with other proteins.

E.coli-derived human EPLIN/LIMA1 recombinant protein (Position: R9-E744) .

Ubiquitous. High expression in liver, spleen, pancreas and kidney.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Associates with Ikaros at centromeric heterochromatin.

1. Chen, S., Maul, R. S., Kim, H. R., Chang, D. D. Characterization of the human EPLIN (Epithelial Protein Lost in Neoplasm) gene reveals distinct promoters for the two EPLIN isoforms. Gene 248: 69-76, 2000. 2. Maul, R. S., Chang, D. D. EPLIN, epithelial protein lost in neoplasm. Oncogene 18: 7838-7841, 1999. 3. Maul, R. S., Song, Y., Amann, K. J., Gerbin, S. C., Pollard, T. D., Chang, D. D. EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. J. Cell Biol. 160: 399-407, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39411 MW

6

IKAROS family zinc finger 2

Nucleus.

Zinc finger protein Helios

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.