Anti-EPO/Erytropoëtine Antibody Picoband® fluoro488 Vervoeging

EPO, Erythropoietin, is an acidic glycoprotein hormone with a molecular mass of 34 kD. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. This gene is mapped to 7q22.1. It is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and tubular epithelial cells. It is also produced in perisinusoidal cells in the liver. While liver production predominates in the fetal and perinatal period, renal production is predominant during adulthood. As the prime regulator of red cell production, its major functions are to promote erythroid differentiation and to initiate hemoglobin synthesis. It also has other known biological functions. For example, erythropoietin plays an important role in the brain's response to neuronal injury. EPO is also involved in the wound healing process.

Erythropoietin; Epoetin; EPO

EPO

2056

P01588

Human

No cross-reactivity with other proteins

E. coli-derived human EPO recombinant protein (Position: M1-R166) .

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Flow Cytometry

Angiogenesis, Apoptosis, Atherosclerosis, Cardiovascular, G Protein Signaling, Hematopoietic Progenitors, Hypertrophy, Immunoglobulins, Immunology, Receptors, Signal Transduction, Signaling Pathway, Small G Proteins, Stem Cells, Surface Molecules

Immunogen affinity purified.

Liquid

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

1. Brines, M. L., Ghezzi, P., Keenan, S., Agnello, D., de Lanerolle, N. C., Cerami, C., Itri, L. M., Cerami, A.Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury.Proc. Nat. Acad. Sci. 97: 10526-10531, 2000. 2. Casals-Pascual, C., Idro, R., Gicheru, N., Gwer, S., Kitsao, B., Gitau, E., Mwakesi, R., Roberts, D. J., Newton, C. R. J. C.High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria.Proc. Nat. Acad. Sci. 105: 2634-2639, 2008. 3. Celik, M., Gokmen, N., Erbayraktar, S., Akhisaroglu, M., Konakc, S., Ulukus, C., Genc, S., Genc, K., Sagiroglu, E., Cerami, A., Brines, M.Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.Proc. Nat. Acad. Sci. 99: 2258-2263, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

21307 MW

No cross reactivity with other proteins.

6

Erythropoietin

Secreted.

Belongs to the EPO/TPO family.

Erythropoietin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.