Anti-ESPN Antibody Picoband®

This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement.

Boster Bio Anti-ESPN Antibody Picoband® catalog # A06536. Tested in WB, ELISA applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

ESPN; DFNB36; LP2654; Espin; Autosomal recessive deafness type 36 protein; Ectoplasmic specialization protein

ESPN

83715

B1AK53

Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human ESPN recombinant protein (Position: H143-Y854) . Human ESPN shares 75.6% and 78.1% amino acid (aa) sequence identity with mouse and rat ESPN, respectively.

WB, ELISA

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

1. Ahmed, Z. M., Jaworek, T., Sarangdhar, G. N., Zheng, L., Gul, K., Khan, S. N., Friedman, T. B., Sisk, R. A., Bartles, J. R., Riazuddin, S., Riazuddin, S. Inframe deletion of human ESPN is associated with deafness, vestibulopathy and vision impairment. J. Med. Genet. 55: 479-488, 2018. 2. Bartles, J. R., Wierda, A., Zheng, L. Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializations. J. Cell Sci. 109: 1229-1239, 1996. 3. Bartles, J. R., Zheng, L., Li, A., Wierda, A., Chen, B. Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli. J. Cell Biol. 143: 107-119, 1998.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A06536

92 kDa

110 kDa

Espin

Espin

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.