Anti-Factor VIII/F8 Antibody Picoband® fluoro488 Vervoeging

Coagulation Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF) . By in situ hybridization, Tantravahi et al. (1986) concluded that the F8 gene is located in the proximal part of chromosome Xq28 with probes DX13 and St14 distally located. The F8 gene encodes coagulation factor VIII, a large plasma glycoprotein that functions in the blood coagulation cascade as a cofactor for the factor IXa-dependent activation of factor X (F10) . Factor VIII is activated proteolytically by a variety of coagulation enzymes, including thrombin (F2) . Factor VIII is tightly associated in the blood with von Willebrand factor (VWF), which serves as a protective carrier protein for factor VIII (Toole et al., 1984; Hoyer, 1994) .

Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain; F8; F8C

F8

2157

P00451

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human Factor VIII.

Flow Cytometry

Angiogenesis, Cancer, Cardiovascular, Invasion/Microenvironment, Platelets, Serum Proteins, Stem Cells

Immunogen affinity purified.

Liquid

Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.

1. Hoyer, L. W. Hemophilia A. New Eng. J. Med. 330: 38-45, 1994. 2. Tantravahi, U., Murty, V. V. V. S., Jhanwar, S. C., Toole, J. J., Woozney, J. M., Chaganti, R. S. K., Latt, S. A. Physical mapping of the factor VIII gene proximal to two polymorphic DNA probes in human chromosome band Xq28: implications for factor VIII gene segregation analysis. Cytogenet. Cell Genet. 42: 75-79, 1986. 3. Toole, J. J., Knopf, J. L., Wozney, J. M., Sultzman, L. A., Buecker, J. L., Pittman, D. D., Kaufman, R. J., Brown, E., Shoemaker, C., Orr, E. C., Amphlett, G. W., Foster, W. B., Coe, M. L., Knutson, G. J., Fass, D. N., Hewick, R. M. Molecular cloning of a cDNA encoding human antihaemophilic factor. Nature 312: 342-347, 1984.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

267009 MW

No cross reactivity with other proteins.

6

Coagulation factor VIII

Secreted, extracellular space.

Belongs to the multicopper oxidase family.

Coagulation factor VIII

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.