Anti-FADS1 Antibody Picoband® fluoro488 Vervoeging

Fatty acid desaturase 1 is an enzyme that in humans is encoded by the FADS1 gene. The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

Natural killer cell receptor 2B4; Cd244; LOC685808

FADS1

3992

O60427

Human

No cross-reactivity with other proteins.

E.coli-derived human FADS1 recombinant protein (Position: M1-M257) .

Expressed in natural killer (NK) cells, T cells and dendritic cells.

Flow Cytometry

Cancer, Cancer Metabolism, Cardiovascular, Growth Factors/Hormones, Metabolism, Metabolism Processes, Pathways and Processes, Response To Hypoxia, Signal Transduction, Vasculature

Immunogen affinity purified.

Liquid

Modulate other receptor-ligand interactions to enhance leukocyte activation.

1. Ameur, A., Enroth, S., Johansson, A., Zaboli, G., Igl, W., Johansson, A. C. V., Rivas, M. A., Daly, M. J., Schmitz, G., Hicks, A. A., Meitinger, T., Feuk, L., van Duijn, C., Oostra, B., Pramstaller, P. P., Rudan, I., Wright, A. F., Wilson, J. F., Campbell, H., Gyllensten, U. Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids. Am. J. Hum. Genet. 90: 809-820, 2012. 2. Cho, H. P., Nakamura, M., Clarke, S. D. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. J. Biol. Chem. 274: 37335-37339, 1999. 3. Marquardt, A., Stohr, H., White, K., Weber, B. H. F. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics 66: 175-183, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

87164 MW

6

CD244 molecule

Integral component of membrane

Endothelin-converting enzyme 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.