Anti-FAM59A GAREM1 Antilichaam

FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.

Boster Bio Anti-FAM59A GAREM1 Antibody (Catalog # A12630) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Gm944, FAM59A, C18orf11, GRB2-associated and regulator of MAPK protein, GRB2-associated and regulator of MAPK1

FAM59A

Q9H706

Human, Mouse, Rat

FAM59A antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FAM59A. The immunogen is located within amino acids 630 - 680 of FAM59A.

Isoform 1 is ubiquitously expressed.

ELISA, WB, IHC-P, IF

Cancer

FAM59A Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.

FAM59A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A12630

97186 MW

Family with sequence similarity 59, member A

Family with sequence similarity 59, member A

IgG

FAM59A Antibody is supplied in PBS containing 0.02% sodium azide.