Anti-FBXW8 Antibody Picoband® fluoro488 Vervoeging

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

FBXW8; FBW6; FBW8; FBX29; FBXO29; FBXW6; F-box/WD repeat-containing protein 8; F-box and WD-40 domain-containing protein 8; F-box only protein 29

FBXW8

26259

Q8N3Y1

Human, Rat

No cross-reactivity with other proteins

E.coli-derived human FBXW8 recombinant protein (Position: M1-V598) . Human FBXW8 shares 78.5% and 77.4% amino acid (aa) sequence identity with mouse and rat FBXW8, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Arai, T., Kasper, J. S., Skaar, J. R., Ali, S. H., Takahashi, C., DeCaprio, J. A. Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc. Nat. Acad. Sci. 100: 9855-9860, 2003. 2. Dias, D. C., Dolios, G., Wang, R., Pan, Z.-Q. CUL7: A DOC domain-containing cullin selectively binds Skp1-Fbx29 to form an SCF-like complex. Proc. Nat. Acad. Sci. 99: 16601-16606, 2002. 3. Jin, J., Cardozo, T., Lovering, R. C., Elledge, S. J., Pagano, M., Harper, J. W. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 18: 2573-2580, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67 kDa

6

F-box and WD repeat domain containing 8

F-box/WD repeat-containing protein 8

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.